A pathological study of liver disease in animals

Mackay, J. M.K (1960) A pathological study of liver disease in animals. PhD thesis, University of Glasgow.

Abstract

The thesis is divided into two sections. The first of these describes the occurrence and isolation of a strain of ectromelia virus from an epidemic in which skin lesions were not a notable feature. The outstanding feature at necropsy in these cases was a regularly occurring hepatitis. The identity of the agent was confirmed by means of egg inoculation, virus neutralisation and haemagglutination tests, and it was considered that the disease might serve as a useful experimental model of infective hepatitis. The second section of the theses deals with the effects of environmental factors on the development of the diseased produced by the virus. Protein deficient diets were selected on the basis of their ability to produce dietetic necrosis in rats. Two such diets which differed only in the source of casein used failed to influence adversely the development of hepatitis due to the virus. The effect of a cold environment was next investigated and it was demonstrated that the 50 per cent. lethal dose end-point was much higher in the cold environment. The results were highly significant and indicated that a hundred to a thousand times as much virus is required to kill approximately 50 percent. of mice in the warm environment used (approximately 75

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: J W Emelie
• Keywords: Animal diseases, Virology
• Date of Award: 1960
• Depositing User: Enlighten Team
• Unique ID: glathesis:1960-73840
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jun 2019 08:56
• Last Modified: 14 Jun 2019 08:56
• URI: https://theses.gla.ac.uk/id/eprint/73840