Development of aliphatic thiosulfonates as cysteine protease inhibitors

Pirvan, Petrisor-Alin (2019) Development of aliphatic thiosulfonates as cysteine protease inhibitors. MSc(R) thesis, University of Glasgow.

Abstract

Cysteine proteases are implicated in a wide range of biological processes, which makes them an important factor in the pathogenesis of many diseases. Dysregulation of protease activity can lead to various diseases such as cancer, osteoporosis, neurological disorders and cardiovascular diseases. Furthermore, cysteine proteases have been proved to play a critical role in the life cycle of parasitic infections, an issue that grows every year due to increasing human migration. Therefore, cysteine proteases show great potential as targets for medicinal chemists.
The following work aims to address this area of research through the synthesis of non-natural amino acid derived thiosulfonate warheads.

• Item Type: Thesis (MSc(R))
• Qualification Level: Masters
• Keywords: cysteine proteases inhibitors, aliphatic thiosulfonates, thiosulfonates.
• Subjects: Q Science > QD Chemistry
• Colleges/Schools: College of Science and Engineering > School of Chemistry
• Supervisor's Name: Liskamp, Professor Robert
• Date of Award: 2019
• Depositing User: Mr Petrisor-Alin Pirvan
• Unique ID: glathesis:2019-74260
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 20 Jun 2019 15:00
• Last Modified: 07 Aug 2020 15:54
• URI: https://theses.gla.ac.uk/id/eprint/74260