Molecular Biology of Fulminant Hepatitis B Viruses

Yasmin, Mahmuda (1997) Molecular Biology of Fulminant Hepatitis B Viruses. PhD thesis, University of Glasgow.

Abstract

Fulminant hepatitis B (FHBV) is a rare but severe outcome of acute hepatitis B virus infection. The severe liver injury is attributed to an exaggerated immune response directed at clearing virus by causing lysis of infected hepatocytes. Multiple factors could contribute to severity of the disease. Our study has shown that although there are no specific variant(s) linked to severity, there are clusters of variants in the cis-acting regulatory elements which can upregulate replication of FHBV strains. The most novel concept to come out of this study is that, most of these variants are not unique to FHBV sequences but they are significant when they occur in the form of 'motifs' or combinations; we showed that these multiple motifs are associated with a common functional effect.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Bill Carman
• Keywords: Virology
• Date of Award: 1997
• Depositing User: Enlighten Team
• Unique ID: glathesis:1997-74462
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 27 Sep 2019 18:14
• Last Modified: 27 Sep 2019 18:14
• URI: https://theses.gla.ac.uk/id/eprint/74462