Studies Into the MAP Kinase Pathway of Cells Transformed by the FBR Murine Sarcoma Virus and Their Revertants

Katsanakis, Konstantinos D (1998) Studies Into the MAP Kinase Pathway of Cells Transformed by the FBR Murine Sarcoma Virus and Their Revertants. PhD thesis, University of Glasgow.

Abstract

Neoplastic transformation by the FBR fos oncogene is associated with aspects of the transformed phenotype such as morphological alterations, anchorage-independent growth and metastasis. The products of the FBR and FBJ fos oncogenes are members of the transcription factor AP-1, which operates downstream of the growth factor - ras - MAP Kinase pathway in mammalian cells. The constituents of this pathway, such as the protein kinases Raf-1 and MEK- 1 are necessary for normal and oncogenic cell growth.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Brad Ozanne
• Keywords: Medicine, Cellular biology
• Date of Award: 1998
• Depositing User: Enlighten Team
• Unique ID: glathesis:1998-74516
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 13 Nov 2019 15:58
• Last Modified: 13 Nov 2019 15:58
• URI: http://theses.gla.ac.uk/id/eprint/74516