Russell, Alan John
(1993)
Molecular Genetics of Human 3beta-Hydroxysteroid Dehydrogenase Deficiency.
PhD thesis, University of Glasgow.
Full text available as:
Abstract
3beta-hydroxysteroid dehydrogenase (3beta-HSD) catalyses a series of obligatory biosynthetic steps in the synthesis of mineralocorticoids, glucocorticoids and sex steroids. Specifically, it converts the 3beta-hydroxysteroids pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, and androstene 3beta,1713-diol into the respective 3beta4 3-ketosteroids: progesterone, 17alpha-hydroxyprogesterone, androstenedione and testosterone. In rodents at least three genes for 3beta-HSD have been found to be expressed. When analysed on southern blots, human DNA shows evidence of six or more sequences with homology to 3beta-HSD probes. So far, two highly homologous but distinct human genes have been cloned, encoding 3beta-HSD type I expressed principally in the placenta, and 3beta-HSD type II expressed in adrenal, ovary and testis. Though the type I and II enzymes differ in their kinetics in detail, they are both capable of converting the same 3beta5 substrates.
Item Type: |
Thesis
(PhD)
|
Qualification Level: |
Doctoral |
Additional Information: |
Adviser: Roger G Sutcliffe |
Keywords: |
Genetics |
Date of Award: |
1993 |
Depositing User: |
Enlighten Team
|
Unique ID: |
glathesis:1993-74521 |
Copyright: |
Copyright of this thesis is held by the author. |
Date Deposited: |
27 Sep 2019 17:58 |
Last Modified: |
27 Sep 2019 17:58 |
URI: |
http://theses.gla.ac.uk/id/eprint/74521 |
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