Biochemical Screening for Fetal Chromosome Abnormalities

Crossley, Jennifer A (1993) Biochemical Screening for Fetal Chromosome Abnormalities. PhD thesis, University of Glasgow.

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The aim of this project was to explore ways of using biochemical screening to improve the prenatal detection rate for Down's syndrome and other chromosome abnormalities over that being achieved using maternal age alone. It is well established that the risk of a pregnancy being affected by Down's syndrome or one of the other autosomal trisomies increases with advancing maternal age, and since the early 1970s this has been the criterion used to select women for diagnostic fetal chromosome analysis. However, the majority of affected pregnancies (70%) are born to women under 35 years of age and the uptake of diagnostic testing amongst women aged 35 years and over has been relatively low (<40%) leading to only around 12% of the affected pregnancies being detected in practice.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: David Aitken
Keywords: Medicine, Biochemistry, Medical ethics
Date of Award: 1993
Depositing User: Enlighten Team
Unique ID: glathesis:1993-74597
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 13 Nov 2019 15:58
Last Modified: 13 Nov 2019 15:58

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