Some Aspects of Gastric Disease in the Dog

Sullivan, Martin (1993) Some Aspects of Gastric Disease in the Dog. PhD thesis, University of Glasgow.

Abstract

Results of detailed investigation of 100 vomiting dogs, including the use of either or endoscopy and radiology as a means of diagnosis are presented. Endoscopy proved to be better of the two investigative aids as it allowed widespread examination of the gastric mucosa, but it was decided that both methods should be applied as they compliment each other. Many of the canine patients examined endoscopically were found to have bile present in their stomachs or actively refluxing, which was interpreted as a duodenogastric reflux gastritis in these vomiting dogs. However, a number of control dogs also had bile reflux identified to varying degrees. A number of dogs were found to have peptic ulcers that had been caused or exacerbated by the ingestion of non-steroidal antiinflammatory drugs. Most were managed successfully by the short term administration of receptor antagonists and the cessation of non-steroidal antiinflammatory drug therapy. However, the severity of the degenerative joint disease required the continued use of non-steroidal anti-inflammatory drug with the concomitant use of H2 antagonist in one dog to prevent the unwanted gastric-side effects. The results of the studies on the vomiting dogs indicated clearly that gastric abnormalities in this species are, as yet, not fully understood and the diagnosis, treatment and prevention of gastric abnormalities warrants further investigation. The effect on the gastric mucosa of the administration of acid, bile and two nonsteroidal anti-inflammatory drugs (aspirin and carprofen) individually and in combination was studied in the rat. It was found that carprofen appeared to cause as much damage as aspirin and that this damage was exacerbated by the concomitant administration of bile. The effect of prior treatment of the rats with famotidine, an H2 receptor antagonist, or sucralfate, a mucoprotective drug, before challenge with aspirin and carprofen both appeared to effect changes in the mucosa, but that sucralfate appeared to be slightly better in its effect on the gastric mucosa, though this was not statistically significant.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: N T Gorman
• Keywords: Veterinary science, Animal diseases
• Date of Award: 1993
• Depositing User: Enlighten Team
• Unique ID: glathesis:1993-75339
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Dec 2019 09:15
• Last Modified: 19 Dec 2019 09:15
• URI: https://theses.gla.ac.uk/id/eprint/75339