Synthetic Studies Directed Towards the Sesquiterpenoid Grimaldone

Calderwood, David John (1993) Synthetic Studies Directed Towards the Sesquiterpenoid Grimaldone. PhD thesis, University of Glasgow.

Abstract

An advanced intermediate in a route to the odoriferous sesquiterpenoid grimaldone has been synthesised using a formal [3+2] cycloaddition reaction as the key step. Subsequent transformation of the intermediate using ring-contraction methodology developed by House failed. Therefore, a new route to grimaldone was devised involving a modified Sharpless oxidative cleavage reaction. Again, an advanced intermediate was attained and model studies on that compound have indicated that a very late-stage precursor to grimaldone can be accessed relatively easily.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: E W Calvin
• Keywords: Organic chemistry
• Date of Award: 1993
• Depositing User: Enlighten Team
• Unique ID: glathesis:1993-75441
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 20:07
• Last Modified: 19 Nov 2019 20:07
• URI: https://theses.gla.ac.uk/id/eprint/75441