Synthetic Studies Directed Towards the Sesquiterpenoid Grimaldone

Calderwood, David John (1993) Synthetic Studies Directed Towards the Sesquiterpenoid Grimaldone. PhD thesis, University of Glasgow.

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An advanced intermediate in a route to the odoriferous sesquiterpenoid grimaldone has been synthesised using a formal [3+2] cycloaddition reaction as the key step. Subsequent transformation of the intermediate using ring-contraction methodology developed by House failed. Therefore, a new route to grimaldone was devised involving a modified Sharpless oxidative cleavage reaction. Again, an advanced intermediate was attained and model studies on that compound have indicated that a very late-stage precursor to grimaldone can be accessed relatively easily.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: E W Calvin
Keywords: Organic chemistry
Date of Award: 1993
Depositing User: Enlighten Team
Unique ID: glathesis:1993-75441
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 19 Nov 2019 20:07
Last Modified: 19 Nov 2019 20:07

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