Biological Equivalence Between Different Radiotherapy Schedules Studied Using the Linear Quadratic Model

Deehan, Charles (1995) Biological Equivalence Between Different Radiotherapy Schedules Studied Using the Linear Quadratic Model. PhD thesis, University of Glasgow.

Abstract

The aim of this work was to investigate biological equivalence between different radiotherapy treatment schedules. The first three chapters form an introduction to radiobiological aspects of radiotherapy, these discuss radiation effects on cells and tissues, radiobiological models in radiotherapy and biological equivalence. In chapters 4, 5 and 6 conditions for general equivalence are derived for fractionated, continuous and combined treatments, based on biological effect calculations performed at specific points in a dose distribution. Chapters 7 and 8 introduce the subject of iso-effect surfaces and this concept is applied to both continuous and fractionated treatments. Finally results of this thesis are compared with clinical reports in chapter 9. The Linear Quadratic (LQ) iso-effect model is used in the derivation of general equivalence relationships and in iso-effect surface calculations.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Tom Wheldon
• Keywords: Nuclear physics and radiation, Biophysics
• Date of Award: 1995
• Depositing User: Enlighten Team
• Unique ID: glathesis:1995-75542
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 19:31
• Last Modified: 19 Nov 2019 19:31
• URI: https://theses.gla.ac.uk/id/eprint/75542