Molecular Genetic Analysis of Human Hypertension

Nasir, Lubna (1993) Molecular Genetic Analysis of Human Hypertension. PhD thesis, University of Glasgow.

Abstract

Hypertension is a major public health problem affecting approximately 15-20% of adult western populations, and is a leading cause of cardiovascular disease and death due to cerebral haemorrage, cardiac failure and kidney disease. Evidence from twin studies, population-based epidemiological studies and adoption studies, demonstrate hypertension is inherited as a multifactorial polygenic trait, where several different genes may be involved in the regulation of blood pressure and the development of high blood pressure. The specific genes involved however are not known, and several potential candidate genes have been identified based on animal and human studies. In the present study the candidate gene approach was employed to identify genetic determinants of high blood pressure in four groups of offspring with contrasting predispositions to high blood pressure; Group A (high offspring blood pressure, low parental blood pressure), Group B (high offspring blood pressure and high parental blood pressure), Group C (low offspring blood pressure and low parental blood pressure) and Group D (low offspring blood pressure high parental blood pressure), in parents with high and low blood pressures and in affected and unaffected sibling pairs. (Abstract shortened by ProQuest.).

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: A Cooke
• Keywords: Genetics, Physiology
• Date of Award: 1993
• Depositing User: Enlighten Team
• Unique ID: glathesis:1993-75610
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 19:18
• Last Modified: 19 Nov 2019 19:18
• URI: https://theses.gla.ac.uk/id/eprint/75610