Partial Synthesis of Novel Trichothecene Mycotoxins

Thomas, Gerard Hugh (1992) Partial Synthesis of Novel Trichothecene Mycotoxins. PhD thesis, University of Glasgow.

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The partial syntheses of two novel trichotheoene homologues, (13R)-3alpha,4beta, 15-triacetoxy-13-methyl-12,13-epoxy trichothec-9-ene (11) and (13S)-3alpha,4beta-triacetoxy-13-methyl-12,13-epoxytrichothec-9-ene (12), from the readily available trichothecenes DAS (1) (4beta,15-diacetoxy-3alpha-hydroxy-12,13-epoxytrichothec-9-ene) and MAS (2) (3alpha,15-dihydroxy-4beta-acetoxy-12,13-epoxytrichothec-9-ene) are detailed. These were carried out in order to provide further insight into the mode of action of the trichothecene mycotoxins. In addition, a model study was conducted which involved the synthesis of the bicyclo[3.2.1]octane epoxy alcohol (96) and the bicyclo[3.2.1]octane epoxy triethylsilyl ethers (110) and (111) from 2-methyl cyclohexanone.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: E W Colvin
Keywords: Organic chemistry, Biochemistry
Date of Award: 1992
Depositing User: Enlighten Team
Unique ID: glathesis:1992-75842
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 19 Dec 2019 09:15
Last Modified: 19 Dec 2019 09:15

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