A Crystallisation Study of the Channel-Forming Membrane Peptide Antibiotic, Gramicidin A

Quigley, Paulene McLean (1998) A Crystallisation Study of the Channel-Forming Membrane Peptide Antibiotic, Gramicidin A. MSc(R) thesis, University of Glasgow.

Abstract

The purpose of the research was to provide a thorough description of the process of crystallisation for the membrane peptide, gramicidin A. This issue will be addressed in two ways. First, I will examine the current literature concerning the theory and process of crystallisation, including issues like solubility and heterogeneity. Having provided and in depth discussion of the crystallisation theory, it will then be specifically applied to the study of ion channel, gramicidin A. From this study, a new set of crystallisation conditions for gramicidin were found in the presence of the detergent. Gramicidin provides a unique case because it represents an interesting union of compounds, small molecules and membrane proteins. For this reason, techniques for both types of compounds will be invoked to study gramicidin's solubility and crystallisation.

• Item Type: Thesis (MSc(R))
• Qualification Level: Masters
• Keywords: Organic chemistry, Pharmacology
• Date of Award: 1998
• Depositing User: Enlighten Team
• Unique ID: glathesis:1998-75875
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 17:41
• Last Modified: 19 Nov 2019 17:41
• URI: https://theses.gla.ac.uk/id/eprint/75875