Studies on retinal antigens with special reference to autoimmunity and analysis by monoclonal antibody technology

Reid, Delyth Marion (1986) Studies on retinal antigens with special reference to autoimmunity and analysis by monoclonal antibody technology. PhD thesis, University of Glasgow.

Abstract

The ability of retina derived antigens to induce a strong immunological response resulting in immunopathological alterations in the retinae of experimentally immunised animals has been well established (reviewed by Faure, 1980). The photoreceptor specific soluble protein, known as S-antigen, has been implicated as one of the most uveitopathogenic components of the retina (Wacker et al. , 1977). There is a growing number of reports suggesting immunological alterations in human retinal degeneration, such as retinitis pigmentosa (RP), and chorioretinal inflammatory diseases, either involving specific retinal autoimmunity or an imbalance in immunological control mechanisms (reviewed by Forrester et al. , 1986). This thesis has sought to further characterise S-antigen, and to examine the specificity of autoimmunity in the RCS rat retinal dystrophic model, human uveitis, and RP.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Biochemistry, Immunology
• Date of Award: 1986
• Depositing User: Enlighten Team
• Unique ID: glathesis:1986-76619
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 14:02
• Last Modified: 19 Nov 2019 14:02
• URI: https://theses.gla.ac.uk/id/eprint/76619