Hepatocytes and Nonregenerative Hepatocyte Cytosol in the Treatment of Acute Hepatic Failure

Buist, Laura Jane (1990) Hepatocytes and Nonregenerative Hepatocyte Cytosol in the Treatment of Acute Hepatic Failure. MD thesis, University of Glasgow.

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Fulminant hepatic failure is a condition associated with a high mortality. The experience of its treatment over a 26 month period in a referral unit for acute liver failure is reviewed. The overall mortality rate was 45% but for those who progressed to grade IV hepatic coma the mortality rate was 73%. These figures represent the results of a combination of medical management and liver transplantation. The largest group of patients referred had developed liver failure due to ingestion of paracetamol (55%), the next largest group had viral hepatitis, mainly non A non B hepatitis (25%) and the others had an assortment of aetiologies including acute Budd-Chiari syndrome and other drug reactions. These different aetiological groups have been considered separately and predictors of outcome determined from their admission and early clinical and laboratory results. In the paracetamol group degree of coma, bilirubin and creatinine levels, hydrogen ion concentration and prothrombin ratio proved to be useful prognostic indicators but in the other two groups these measurements bore no relationship to the ultimate outcome.

Item Type: Thesis (MD)
Qualification Level: Doctoral
Keywords: Medicine
Date of Award: 1990
Depositing User: Enlighten Team
Unique ID: glathesis:1990-76925
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jan 2020 09:27
Last Modified: 14 Jan 2020 09:27
URI: https://theses.gla.ac.uk/id/eprint/76925

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