Characterization and Cloning of MHC Class I Sequences From Choriocarcinoma JEG-3 Cells

Ward, Joanne (1989) Characterization and Cloning of MHC Class I Sequences From Choriocarcinoma JEG-3 Cells. PhD thesis, University of Glasgow.

Abstract

1. The use of sera and monoclonal antibodies has permitted the serological definition of three polymorphic genetic loci HLA-A, HLA-B, and HLA-C, which encode the 45kDa heavy chains of the classical class I transplantation antigens. These molecules were identified because they elicited strong allograft rejection. Their true function is to serve as restriction elements by presenting peptidic antigens for recognition by cytotoxic T lymphocytes in MHC restricted responses. Molecular genetic analyses revealed that the vertebrate class I gene family was larger than expected, and there is evidence that at least some of these genes encode polypeptides whose structure and perhaps function is different from those of the classical class I loci.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Genetics, Cellular biology
• Date of Award: 1989
• Depositing User: Enlighten Team
• Unique ID: glathesis:1989-76977
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:25
• Last Modified: 14 Jan 2020 09:25
• URI: https://theses.gla.ac.uk/id/eprint/76977