Studies on Atrial Natriuretic Peptide

Jardine, Alan George (1991) Studies on Atrial Natriuretic Peptide. MD thesis, University of Glasgow.

Abstract

Atrial Natriuretic Peptide (ANP) is a hormone secreted by the heart with a unique spectrum of actions: natriuresis, diuresis, vasorelaxation and suppression of the renin-angiotensin system. This thesis is divided into four sections each of which examines a different aspect of ANP. The common theme is the question of how the actions of ANP may be "harnessed" therapeutically, either directly using novel inhibitors of the enzyme Neutral Endopeptidase (NEP; EC 3.4.24.11) which degrades ANP, or indirectly, by investigating potential interactions with available therapeutic agents including Angiotensin Converting Enzyme (ACE) inhibitors, and calcium channel blockers.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine, Endocrinology
• Date of Award: 1991
• Depositing User: Enlighten Team
• Unique ID: glathesis:1991-77077
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:21
• Last Modified: 14 Jan 2020 09:21
• URI: https://theses.gla.ac.uk/id/eprint/77077