McClue, Steven J
(1991)
Interaction of alpha2-Adrenergic Receptors With G-Proteins.
PhD thesis, University of Glasgow.
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Abstract
A wide variety of hormones and neurotransmitters have been shown to produce intracellular signals mediated by guanine-nucleotide binding proteins (G-proteins). These have been shown to form a link between receptors on the extracellular face of the cell membrane, and their intracellular second-message-generating effectors, such as phospholipase C and adenylyl cyclase. An increasing number of different heterotrimeric G-proteins have been isolated, with varying degrees (50-95%) of sequence homology. This similarity of sequence has raised questions of specificity of interaction of G-proteins: do individual G-proteins interact only with specific receptors and effectors, or are they more promiscuous in their interaction? This question has been addressed by examining the specificity of coupling of G-proteins to alpha2-adrenergic receptors in two model systems.
| Item Type: |
Thesis
(PhD)
|
| Qualification Level: |
Doctoral |
| Keywords: |
Biochemistry, Molecular biology |
| Date of Award: |
1991 |
| Depositing User: |
Enlighten Team
|
| Unique ID: |
glathesis:1991-77092 |
| Copyright: |
Copyright of this thesis is held by the author. |
| Date Deposited: |
14 Jan 2020 09:20 |
| Last Modified: |
14 Jan 2020 09:20 |
| URI: |
http://theses.gla.ac.uk/id/eprint/77092 |
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