McCrae, James McGenchie
(1966)
Studies in Cycloheptenes.
PhD thesis, University of Glasgow.
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Abstract
Part I. Chapter 1 describes a synthesis of the colchicine skeleton, namely, desmethoxydesacetamido-8,9,10,11,12-hexahydrocolchicine. This was accomplished by utilising the bridge-cleavage reaction of a bicyclo-(3,2,1)-octan-8-one to the cycloheptene carboxylic acid. The acid produced was elaborated, via its methyl ketone to an 0-acetate which on reduction, yielded the above alcohol. In chapter 2 this cleavage reaction was employed in an unambiguous and selective synthesis of beta-carboxytropolone.
| Item Type: |
Thesis
(PhD)
|
| Qualification Level: |
Doctoral |
| Keywords: |
Organic chemistry |
| Date of Award: |
1966 |
| Depositing User: |
Enlighten Team
|
| Unique ID: |
glathesis:1966-77192 |
| Copyright: |
Copyright of this thesis is held by the author. |
| Date Deposited: |
14 Jan 2020 09:16 |
| Last Modified: |
14 Jan 2020 09:16 |
| URI: |
http://theses.gla.ac.uk/id/eprint/77192 |
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