Synthetic Routes to 14-Aminocodeinone Derivatives

Gourlay, Ross Ian (1979) Synthetic Routes to 14-Aminocodeinone Derivatives. PhD thesis, University of Glasgow.

Abstract

The synthesis of 14beta-acylaminocodeinones has been achieved via the Diels-Alder addition of nitrosocarbonyl-compounds to the activated diene system of the baine. Several variations on this route have been investigated and the most efficient yields the desired products in greater than 60% yield from the baine. The analgesic properties and structure/activity relationships of several of these compounds and their precursors with differing alkyl and aryl side chains have been established.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Organic chemistry
• Date of Award: 1979
• Depositing User: Enlighten Team
• Unique ID: glathesis:1979-77223
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:15
• Last Modified: 14 Jan 2020 09:15
• URI: https://theses.gla.ac.uk/id/eprint/77223