Biosynthesis of Gliotoxin and Related Compounds

Patrick, Graham L (1979) Biosynthesis of Gliotoxin and Related Compounds. PhD thesis, University of Glasgow.

Abstract

The open chain dipeptides, L-phenylalanyl-L-serine and L-seryl-L-phenylalanine were synthesised, radioactively labelled with 14C and 3H. Both precursors were poorly incorporated into gliotoxin, produced by Trichoderma viride. The isotope ratio measured in gliotoxin was different from those of the precursors which suggested that the precursors were cleaved by the fungus to their constituent amino-acids. It is believed that the amino-acids were then incorporated separately into gliotoxin.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Organic chemistry
• Date of Award: 1979
• Depositing User: Enlighten Team
• Unique ID: glathesis:1979-77226
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 11:53
• Last Modified: 14 Jan 2020 11:53
• URI: https://theses.gla.ac.uk/id/eprint/77226