Studies on the Biosynthesis of Bis-Lactone Antibiotics

Johnston, Grant Alexander (1979) Studies on the Biosynthesis of Bis-Lactone Antibiotics. PhD thesis, University of Glasgow.

Abstract

In this research it has been shown by incorporation experiments using synthetic, labelled precursors that the antibiotics ethisolide (1) and canadensolide (2) have closely related biosynthetic origins in the appropriately substituted citric acids derived from condensation of a fatty acid derived moiety with a TCA cycle acid (probably oxaloacetate). The most convincing evidence to date for this pathway comes from the efficient and specific incorporation by P. canaderse of alpha-n-hexylitaconic acid into canadensolide (2) and the related metabolites.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Organic chemistry
• Date of Award: 1979
• Depositing User: Enlighten Team
• Unique ID: glathesis:1979-77228
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:15
• Last Modified: 14 Jan 2020 09:15
• URI: https://theses.gla.ac.uk/id/eprint/77228