Synthesis of Nuclearly-Modified Cephalosporin Antibiotics

Gallacher, Gerard (1980) Synthesis of Nuclearly-Modified Cephalosporin Antibiotics. PhD thesis, University of Glasgow.

Abstract

Approaches are described towards synthesis of 1-hydroxy-1-carba-cephalosporin (1), a chemically interesting nuclearly modified cephalosporin analogue which may possess potent antibiotic activity. Approaches to a bicyclic tetrahydropyridine (27), potentially convertible into carbacephem (1), are also discussed. Oxygenated 1-carbacephems (95) and (97) have been prepared via a route employing the reaction between imines and a ketene precursor to give beta-lactams. The 1alpha-isomer (95) exhibited weak antibiotic properties.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Organic chemistry
• Date of Award: 1980
• Depositing User: Enlighten Team
• Unique ID: glathesis:1980-77241
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:14
• Last Modified: 14 Jan 2020 09:14
• URI: https://theses.gla.ac.uk/id/eprint/77241