Synthesis of Nuclearly-Modified Cephalosporin Antibiotics

Gallacher, Gerard (1980) Synthesis of Nuclearly-Modified Cephalosporin Antibiotics. PhD thesis, University of Glasgow.

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Approaches are described towards synthesis of 1-hydroxy-1-carba-cephalosporin (1), a chemically interesting nuclearly modified cephalosporin analogue which may possess potent antibiotic activity. Approaches to a bicyclic tetrahydropyridine (27), potentially convertible into carbacephem (1), are also discussed. Oxygenated 1-carbacephems (95) and (97) have been prepared via a route employing the reaction between imines and a ketene precursor to give beta-lactams. The 1alpha-isomer (95) exhibited weak antibiotic properties.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Organic chemistry
Date of Award: 1980
Depositing User: Enlighten Team
Unique ID: glathesis:1980-77241
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jan 2020 09:14
Last Modified: 14 Jan 2020 09:14

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