Gallacher, Gerard
(1980)
Synthesis of Nuclearly-Modified Cephalosporin Antibiotics.
PhD thesis, University of Glasgow.
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Abstract
Approaches are described towards synthesis of 1-hydroxy-1-carba-cephalosporin (1), a chemically interesting nuclearly modified cephalosporin analogue which may possess potent antibiotic activity. Approaches to a bicyclic tetrahydropyridine (27), potentially convertible into carbacephem (1), are also discussed. Oxygenated 1-carbacephems (95) and (97) have been prepared via a route employing the reaction between imines and a ketene precursor to give beta-lactams. The 1alpha-isomer (95) exhibited weak antibiotic properties.
| Item Type: |
Thesis
(PhD)
|
| Qualification Level: |
Doctoral |
| Keywords: |
Organic chemistry |
| Date of Award: |
1980 |
| Depositing User: |
Enlighten Team
|
| Unique ID: |
glathesis:1980-77241 |
| Copyright: |
Copyright of this thesis is held by the author. |
| Date Deposited: |
14 Jan 2020 09:14 |
| Last Modified: |
14 Jan 2020 09:14 |
| URI: |
http://theses.gla.ac.uk/id/eprint/77241 |
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