Selective Manipulation of Tumour Cell Energy Metabolism

Sri-Pathmanathan, Rohendra Michael (1988) Selective Manipulation of Tumour Cell Energy Metabolism. PhD thesis, University of Glasgow.

Abstract

Rapidly growing, glycolytic tumours which are poorly differentiated were shown to contain functional mitochondria capable of oxidative phosphorylation. Mitochondria were isolated and assessed for use in screening potential antimitochondrial agents in vitro. As this model proved to be unsuitable, a second model, intact cells were employed for screening purposes. The effect of antimitochondrial agents on the metabolism of cultured tumour cells was compared to that in freshly isolated rat hepatocytes.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Medicine, Physiology, Cellular biology, Oncology
• Date of Award: 1988
• Depositing User: Enlighten Team
• Unique ID: glathesis:1988-77263
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 11:53
• Last Modified: 14 Jan 2020 11:53
• URI: https://theses.gla.ac.uk/id/eprint/77263