McLellan, Alastair Robert
(1991)
G-Proteins in N.I.D.D.M. and Hypertension.
MD thesis, University of Glasgow.
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Abstract
G-proteins are guanine-nucleotide-binding regulatory proteins which couple receptors to effector mechanisms; G-protein associated 'second messengers' include cAMP and the phospho-inositides, while other G-proteins are coupled to calcium and potassium channels. The expanding G-protein family (all of which share a common trimeric structure) currently includes at least 12 distinct G-proteins some of which can be identified in plasma membranes using specific antibodies (Western immuno-blotting): antibodies are available against several a subunits (Gsa, Gia1, Gia2, Gia3 and Goa)(which possess receptor and effector binding sites) as well as against B subunits. Function has not yet been ascribed to all G-proteins, but Gsa and Gia2 are concerned with the dual regulation (respectively stimulating and inhibiting) of adenylyl cyclase (AC) catalytic unit activity (A).
Item Type: |
Thesis
(MD)
|
Qualification Level: |
Doctoral |
Keywords: |
Medicine |
Date of Award: |
1991 |
Depositing User: |
Enlighten Team
|
Unique ID: |
glathesis:1991-77278 |
Copyright: |
Copyright of this thesis is held by the author. |
Date Deposited: |
14 Jan 2020 11:53 |
Last Modified: |
14 Jan 2020 11:53 |
URI: |
http://theses.gla.ac.uk/id/eprint/77278 |
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