G-Proteins in N.I.D.D.M. and Hypertension

McLellan, Alastair Robert (1991) G-Proteins in N.I.D.D.M. and Hypertension. MD thesis, University of Glasgow.

Abstract

G-proteins are guanine-nucleotide-binding regulatory proteins which couple receptors to effector mechanisms; G-protein associated 'second messengers' include cAMP and the phospho-inositides, while other G-proteins are coupled to calcium and potassium channels. The expanding G-protein family (all of which share a common trimeric structure) currently includes at least 12 distinct G-proteins some of which can be identified in plasma membranes using specific antibodies (Western immuno-blotting): antibodies are available against several a subunits (Gsa, Gia1, Gia2, Gia3 and Goa)(which possess receptor and effector binding sites) as well as against B subunits. Function has not yet been ascribed to all G-proteins, but Gsa and Gia2 are concerned with the dual regulation (respectively stimulating and inhibiting) of adenylyl cyclase (AC) catalytic unit activity (A).

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine
• Date of Award: 1991
• Depositing User: Enlighten Team
• Unique ID: glathesis:1991-77278
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 11:53
• Last Modified: 14 Jan 2020 11:53
• URI: http://theses.gla.ac.uk/id/eprint/77278