A Study of the Effect of Local and Distant Sepsis on the Patency of Microvascular Anastomoses

McLean, Neil Robert (1991) A Study of the Effect of Local and Distant Sepsis on the Patency of Microvascular Anastomoses. MD thesis, University of Glasgow.

Abstract

1. Introduction. Although Carrel laid the basic foundations of organ transplantation, vascular anastomosis and free tissue transfer in the early part of this century, it was not until almost 50 years later that the first successful free flap was reported by Seidenberg and colleagues. Now, using refined instrumentation, success rates of around 90% are reported in most large clinical studies involving the microvascular transfer of free tissues. Many factors such as technique, irradiation, tension, diabetes and nicotine, are known to influence the patency of a micro-vascular anastomosis, but although the role of infection in vascular practice has been well documented, to date, little work has been published on the effect of sepsis on a micro-vascular repair. The purpose of this study in the rat experimental model, was to investigate the role of distant septic inflammation, distant sterile inflammation, local wound sepsis and a transient sub-lethal bacteraemia on the patency of microvascular anastomoses.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine, Surgery
• Date of Award: 1991
• Depositing User: Enlighten Team
• Unique ID: glathesis:1991-77294
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:13
• Last Modified: 14 Jan 2020 09:13
• URI: https://theses.gla.ac.uk/id/eprint/77294