Monocyte C1-Inhibitor Synthesis

Jones, Linda Margaret (1987) Monocyte C1-Inhibitor Synthesis. PhD thesis, University of Glasgow.

Abstract

C1-inhibitor is the major control protein of the classical pathway of complement. In man, its hereditary deficiency results in the clinical condition of hereditary angio-oedema (HAE). The disease is characterised by recurrent episodes of acute, circumscribed, non-inflammatory oedema involving the subcutaneous tissues and mucous membranes. Acquired C1-inhibitor deficiency can also occur without any previous family history, at a later stage in life and is usually associated with a lymphoproliferative disorder or paraproteinaemia. C1-inhibitor deficiency is treated by the administration of anabolic steroids, such as danazol or stanozolol, which are known to increase hepatic synthesis of C1-inhibitor, resulting in an increase in plasma C1-inhibitor.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Molecular biology
• Date of Award: 1987
• Depositing User: Enlighten Team
• Unique ID: glathesis:1987-77530
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 11:53
• Last Modified: 14 Jan 2020 11:53
• URI: https://theses.gla.ac.uk/id/eprint/77530