Colonization and Penetration of the Stratum Corneum by Dermatophyte Fungi

Al-Jabre, Salih Hamad Mohamad (1990) Colonization and Penetration of the Stratum Corneum by Dermatophyte Fungi. PhD thesis, University of Glasgow.

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The colonization and penetration of stratum corneum by dermatophyte fungi were investigated employing arthrospores of three strains, two of Trichophyton mentagrophytes and one of Trichophyton interdigitale. The adherence of arthrospores to corneocytes from palm and sole and germination in suspensions of corneocytes from the same body areas were determined. The growth of arthrospores on stripped sheets of stratum corneum from different body areas, namely, sole, leg, groin, abdomen, back, cheek, forearm, and palm, was also studied. The ultrastructure of corneocyte and stratum corneum - dermatophyte relationship was investigated by scanning and transmission electronmicroscopy. Scale from cases of tinea pedis was also investigated ultrastructurally. The resistance of arthrospores to ordinary environmental and desiccated conditions in the presence and absence of corneocytes was studied and the type of dormancy expressed by arthrospores was investigated. The effect of exposing arthrospores to distilled water for 24 hr on their germination in corneocyte suspensions and on stratum corneum was studied. The possibility of using corneocytes as a model for assessing antifungal activity of drugs against dermatophytes was explored. Two phases of investigation were conducted; phase I consisted of arthrospore germination in corneocyte suspensions in the presence of antifungal drugs and phase II consisted of firstly inducing arthrospore germination in corneocyte suspensions then adding antifungal drugs. Arthrospore formation was studied under various cultural conditions; temperature of 37

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Medicine
Date of Award: 1990
Depositing User: Enlighten Team
Unique ID: glathesis:1990-78092
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 28 Feb 2020 12:09
Last Modified: 28 Feb 2020 12:09

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