The Crystal Structures of Some o-Halogeno-Aroyl Compounds and of a Palmarin Derivative

Islam, Khan Mohammed Sirajul (1967) The Crystal Structures of Some o-Halogeno-Aroyl Compounds and of a Palmarin Derivative. PhD thesis, University of Glasgow.

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This thesis is divided mainly into three sections (see outline): the first section is a brief description of the theory and methods of x-ray crystal structure analysis, the second section describes the crystal structures of four o-halogeno-aroyl compounds and the third one includes the structure of a palmarin derivative. There are two appendices in the thesis. The first one is a brief account of the unsuccessful attempt to solve the structure of phorbol and the second being the improvement of the existing apparatus for Nonius Weissenberg cameras to collect photographic data at low temperature. Section I is divided under nine broad headings giving a short review of the crystal geometry, theory and methods of x-ray crystal structure analysis, refinement of atomic parameters and evaluation of the accuracy of the final results. There are five chapters in Section II. The crystal structure of o-chlorobenzoylacetylene and o-bromobenzoylacetylene are described in the Chapters 1 and 2 respectively. Intramolecular overcrowding and intermolecular ethynyl hydrogen bonds are present in both the structures. Chapter 3 contains the structure of o-fluorobenzoic acid and that of 2-chloro-1,8-phthaloylnaphthalene is described in Chapter 4. The detailed findings of the characteristic features of the conformation, intermolecular hydrogen bonding and intramolecular overcrowding in different o-halogeno-aroyl compounds are discussed in Chapter 5. The crystal structure analysis of p-bromophenacyl derivative of palmarin is described in Section III. The confirmation of the B-epoxide configuration of the palmarin derivative has decided the configuration of the epoxide in a series of Colombo root bitter principleshaving composition C20H22O7 (palmarin, jateorin and chasmanthin) . The structure analysis has also revealed the special distortion of the molecule. A brief account of the unfruitful attempt to solve the structure of phorbol, a natural product, using three different solvate derivatives is given in Appendix A. The short description of the arrangement for taking photographs in the cold nitrogen atmosphere can be seen in Appendix B.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Organic chemistry
Date of Award: 1967
Depositing User: Enlighten Team
Unique ID: glathesis:1967-78443
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 28 Feb 2020 12:09
Last Modified: 28 Feb 2020 12:09

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