The Synthesis of the Macrolide Antibiotic (+/-)-Pyrenophorin

Purcell, Thomas Andrew (1973) The Synthesis of the Macrolide Antibiotic (+/-)-Pyrenophorin. PhD thesis, University of Glasgow.

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The synthesis of the macrolide antibiotic (+/-)-pyrenophorin (1) is described. The molecular sieve promoted cyclisation of the hydroxy methyl ester (135) failed in our hands but the hydroxy-acid (190) was successfully converted to the dithioacetal of (1) using N,N'-carbonyldiimidazole (207) and 1,5-diazabicyclo(4,3,0)-non-5-ene (147). A novel method of removing p-toluenesulphonylethyl esters (166) is reported as is a new simple technique of hydroxyl alkyl-ation involving molecular sieves and sodium hydrogen carbonate.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Organic chemistry, Pharmacology
Date of Award: 1973
Depositing User: Enlighten Team
Unique ID: glathesis:1973-78636
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 30 Jan 2020 15:07
Last Modified: 30 Jan 2020 15:07

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