Some Metabolites of Aspergillus flaschentraegeri

Reid, Ross Donald Lyon (1975) Some Metabolites of Aspergillus flaschentraegeri. PhD thesis, University of Glasgow.

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A new member of the group of compounds known as the cochlioquinones has been isolated from extracts of the culture filtrates of Verticillium lamellicola. It is probable that this new pigment is the dehydro analogue of one of the earlier members of the group, cochlioquinone The biosynthesis of the pimarane-type diterpene antibiotic traegeric acid, isolated from extracts of the culture filtrates of Aspergillus flaschentraegeri, has been shown by 13C-n. m. r. spectroscopy to follow the expected path, via mevalomic acid. The yellow pigment physcion anthrone has been reisolated from mycelial extracts of the same fungus by a novel method which has resulted in greatly increased yields of the metabolite. The biosynthesis of this polyketide-derived pigment has been studied by 13C-n. m. r. spectroscopy. An interesting conformational effect has been observed in the C-10 acetyl derivative of physcion anthrone triacetate. The 10,10' oxidatively coupled dimer of physcion anthrone has been isolated. A novel metabolite, asperflaschin, has been isolated and its biosynthesis studied. The isolation of this compound has necessitated revision of earlier ideas on the biosynthesis of 2-(gamma,gamma-dimethylallyl)-physcion, which has also been reisolated. In this context the isolation of a novel metabolite physcion-2(gamma,gamma-dimethylallyl)-emodin-10,10'-bianthrone may also be of relevance.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Organic chemistry
Date of Award: 1975
Depositing User: Enlighten Team
Unique ID: glathesis:1975-78712
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 30 Jan 2020 15:00
Last Modified: 30 Jan 2020 15:00

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