Synthetic Approaches to Nuclearly-Modified Cephalosporin Antibiotics

Bremner, John Alexander Smith (1977) Synthetic Approaches to Nuclearly-Modified Cephalosporin Antibiotics. PhD thesis, University of Glasgow.

Abstract

Synthetic routes to a 1-hydroxy-1-carbacephem (1), by structure-activity considerations an analogue of potential antibiotic activity, are described. Synthesis of a substituted pyridine for reduction to a cyclic enamine and subsequent annellation to a B-lactam were not successful. An acyclic inline precursor of (1) was prepared but did not yield a beta-lactam by an established annellation procedure. Approaches to a cyclic amine potentially convertible into (1) are described.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Pharmacology
• Date of Award: 1977
• Depositing User: Enlighten Team
• Unique ID: glathesis:1977-78762
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 30 Jan 2020 14:55
• Last Modified: 30 Jan 2020 14:55
• URI: https://theses.gla.ac.uk/id/eprint/78762