Host Resistance and Staphylococcal Infection

Smith, J. Maclean (1956) Host Resistance and Staphylococcal Infection. MD thesis, University of Glasgow.

Abstract

The host response to infection by staphylococci has been studied by death rates, histological studies and the fate of the cocci in the tissues. Different strains of staphylococci have shown a spectrum of virulence detected by quantitative differences in their multiplication in the kidney. When the host metabolism is disturbed by fasting, fasting with glucose solutions to drink or by increased metabolic activity caused by thyroid hormone or dinitrophenol then the animals are more susceptible to staphylococcal infection. Lactate solution given by mouth to fasted animals is beneficial in correcting the susceptibility to infection caused by fasting. Undernutrition, the result of protein or caloric restriction, does not affect the susceptibility of mice to staphylococcal infection. Renal disease is related to death in human cases of staphylococcal infection. It is possible that a mouse virulence test for staphylococci can be developed.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine, Pathology, Microbiology
• Date of Award: 1956
• Depositing User: Enlighten Team
• Unique ID: glathesis:1956-79183
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 05 Mar 2020 11:31
• Last Modified: 05 Mar 2020 11:31
• URI: https://theses.gla.ac.uk/id/eprint/79183