On the Therapeutic Value of Topical Cortisone Acetate in Post-Operative and Post-Traumatic Iridocyclitis

McNaught, Ella I (1958) On the Therapeutic Value of Topical Cortisone Acetate in Post-Operative and Post-Traumatic Iridocyclitis. MD thesis, University of Glasgow.

Abstract

Thirty-two cases of post-operative and post-traumatic iridocyclitis, treated with topical cortisone acetate, are presented. The series was undertaken on the hypothesis that cases of this type provided an example of non-granulomatous iridocyclitis, of known aetiology and often of limited duration, in which cortisone might be expected to be of particular therapeutic value. The mode of action of cortisone is discussed, and the problem of tissue response to injury is considered, with special reference to the possible modifications of this response in the presence of cortisone. Personal observations of thirty-two cases of post-operative and post-traumatic iridocyclitis, treated with sub-conjunctival injections of cortisone acetate, are recorded. Sixteen cases achieved clinical cure of iridocyclitis, but two of these later developed low-grade iridocyclitis in the second eye. Two cases were improved by cortisone, a considerable degree of control of iridocyclitis being obtained. Of the remaining fourteen cases, four relapsed, nine were uninproved, and one responded well initially, but follow-up was inadequate Seventeen eases retained visual acuity of 6/60 or more, and of these, nine retained visual acuity of 6/9 or more. Fourteen cases achieved clinical cure of iridocyclitis and retained useful visual acuity. Fifteen cases failed to retain useful vision, and among these there were eight enucleations. The average period of treatment was five months, and the average follow-up after cortisone had been withdrawn, was nineteen and a half months - these figures exclude one case in which follow-up was inadequate. Ten patients developed skin sensitivity reactions to a variety of drugs while being treated with topical cortisone. Six patients developed kerato-conjunctivitis in the treated eye while receiving topical cortisone. Published reports of the effect of topical cortisone in post-operative and post-traumatic iridocyclitis are reviewed. Comparable cases from hospital records, prior to the use of cortisone, are discussed, and a comparison is made of results of treatment.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine, Pharmaceutical sciences
• Date of Award: 1958
• Depositing User: Enlighten Team
• Unique ID: glathesis:1958-79231
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 05 Mar 2020 11:26
• Last Modified: 05 Mar 2020 11:26
• URI: https://theses.gla.ac.uk/id/eprint/79231