Experimental Studies on Viability, Antigenicity and Persistence of Cartilage Transplants in Rabbits

Craigmyle, M. B. L (1960) Experimental Studies on Viability, Antigenicity and Persistence of Cartilage Transplants in Rabbits. PhD thesis, University of Glasgow.

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1. The history of experimental and clinical transplantation of cartilage is reviewed. 2. Autografts and homografts of fresh costal cartilage in rabbits remain virtually unchanged in various implantation sites for up to two years whereas heterografts of fresh cartilage are almost totally destroyed during a similar period. 3. Histochemical and autoradiographic (using 35S) studies indicate that the cells have remained viable in the autografts and homografts and in a heterograft fragment that had persisted and appeared normal histologically. 4. Cartilage homografts induce a very poor regional lymph node response by comparison with that which has been described for skin homografts of comparable weight. 5. A heterograft of fresh cartilage provokes a much greater regional lymph node response than that produced by a fresh homograft in similar dosage. The capacity of heterografts of boiled cartilage to call forth the lymph node response is weaker than that of fresh heterologous cartilage, 6. Implantation of 0.2 gm. of finely diced homologous cartilage on two occasions will produce a state of transplantation immunity (as determined by the fate of a subsequent skin homo-graft taken from the cartilage donor) in only 28% of hosts. It is known that homologous skin in comparable dosage will render 100% of adult rabbits immune. 7. Cartilage homografts survive and persist in homologous hosts possessing a state of heightened homograft sensitivity induced by a previous skin homograft in high graft dosage (0.4 gm) from the cartilage donor. 8. Cartilage homografts, whose matrix has been degraded by papain and maintained in that condition for about four weeks after grafting, nevertheless survive and persist for at least 3 months in hosts previously sensitised by a skin homograft in high graft dosage from the cartilage donor. 9. Cartilage boiled for up to 10 minutes does not attract host leucocytes after homografting, and persists unaltered for at least 400 days.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Medicine, Surgery
Date of Award: 1960
Depositing User: Enlighten Team
Unique ID: glathesis:1960-79348
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 05 Mar 2020 10:39
Last Modified: 05 Mar 2020 10:39
URI: https://theses.gla.ac.uk/id/eprint/79348

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