The Treatment of Seborrholic Group of Skin Diseases, Sycosis Barbae and Furunculosis With Penicillin

Savage, John (1947) The Treatment of Seborrholic Group of Skin Diseases, Sycosis Barbae and Furunculosis With Penicillin. PhD thesis, University of Glasgow.

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1. Penicillin administered intra-muscularly in a dosage of 500,000 to 1,000,000 units to severe cases of the infected seborrhoea group, sycosis barbae and Furunculosis was thereapeutically superior to any other remedy in controlling infection quickly and safely. 2. The toxic manifestations which occurred when Penicillin was used intra-muscularly were few and unimportant. They were: Fever (4) Fever & urticaria (3): Fever & urticaria and poly arthritis (1). 3. No more effective method of administering Penicillin to cases of skin disease was found than that of Local spray, used in a strength of 1000 un/cc. 4. Three cases of contact type of dermatitis to Penicillin were seen. When the cream was used in the treatment of outpatients the base seemed to irritate the skin of some patients. 5. The results in the infected seborrhoeic group using local Penicillin only were orten good but largely unpredicatable. 31.7% of these cases either failed to improve, or relapsed before healing was complete. Penicillin, however, rarely proved to be clinically harmful in these cases, a most important factor, and unlike Sulphonamide locally, Mercury and Flavine, probably the three commonest preparations used in the initial local treatment or this group to-day. 6. In Sycosis barbae, Penicillin certainly proved valuable, but only as an adjutant to treatment, which, when used with the other members of the team, viz. manual epilation of hairs, eradication of obvious focal sepsis, Quinolor ointment and X-ray therapy produced the best results. 26.37% of patients, however, had a severe relapse at varying times after apparent cure, even although they were still continuing with local treatment. 7. In chronic furunculosis, a course of 500,000 to 1,000,000 units of Penicillin cleared up quickly all existing lesions but did not pretent future relapse. The cases which followed Penicillin with a course of stock vaccine had a slightly smaller relapse rate. In the whole series, however, over 50% of patients had a recurrence within one month of apparent cure.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Medicine
Date of Award: 1947
Depositing User: Enlighten Team
Unique ID: glathesis:1947-79634
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 04 Mar 2020 16:21
Last Modified: 04 Mar 2020 16:21

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