Part I. Experiments in the Colchicine Series. Part II. Studies in the Synthesis of Diazacarbazoles

Ellis, Drummond (1949) Part I. Experiments in the Colchicine Series. Part II. Studies in the Synthesis of Diazacarbazoles. PhD thesis, University of Glasgow.

Abstract

The synthesis of a substance related in structure to colchicine has been completed. The new compound proved to be different from a degradation product of the alkaloid, with which it was isomeric. This observation has a bearing on the structure of colchicine. A preliminary report shows that the substance synthesised inhibits cell-mitosis: a re-evaluation of the structural factors essential for biological activity in this type of substance is consequently regarded as necessary.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Organic chemistry
• Date of Award: 1949
• Depositing User: Enlighten Team
• Unique ID: glathesis:1949-79732
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 31 Mar 2020 09:09
• Last Modified: 31 Mar 2020 09:09
• URI: https://theses.gla.ac.uk/id/eprint/79732