The Pathology of Non-Suppurative Nephritis in Children

Guthrie, Katharine J (1934) The Pathology of Non-Suppurative Nephritis in Children. MD thesis, University of Glasgow.

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Within the last few years many excellent articles have been written dealing with individual aspects of juvenile nephritis, but so far as the present writer is aware, there has appeared recently no monograph of wider scope purporting to give a general review of the pathology of this protean disease in the child, comparable to the studies of nephritis in the adult published by Russell (1929), Addis and Oliver (1931), and Gray (1933). It appeared, therefore, that such an investigation with a survey of the recent literature on the subject might be of some interest. In children nephritis manifests itself in purer form than in adults, since in the former there is no wear and tear of past life to complicate the picture, nor do we have to think of the circulatory system in relation to the kidneys, Hill (1919), while the absence of previous attacks which often complicate the disease in the adult, simplifies the evaluation of the etiological factor in the child, and also the problem of correlating renal structural changes and functional damage, Paterson (1926). In a previous short study of juvenile nephritis by the writer some interesting results emerged even trom the limited series series of cases then investigated - among others the fact that in young children death can take place at a very early stage, with little evidence of disease on macroscopic or even on microscopic examination, and that even when definite pathological changes are evident to the naked-eye, these often form no reliable indication of the type or stage of lesion actually present. Another feature of note was the total absence in many cases of any etiologic factor to which the attack of nephritis might be attributed, though, according to modern views some general or focal infection of etiological significance is rarely lacking. These points have all been more fully investigated in the present study and will be dealt with later.

Item Type: Thesis (MD)
Qualification Level: Doctoral
Keywords: Medicine, Pathology
Date of Award: 1934
Depositing User: Enlighten Team
Unique ID: glathesis:1934-79962
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 03 Mar 2020 10:16
Last Modified: 03 Mar 2020 10:16

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