Some Chemotherapeutic Studies

Snodgrass, W. R (1935) Some Chemotherapeutic Studies. PhD thesis, University of Glasgow.

Abstract

This thesis is primarily the account of two lengthy experiments. The first experiment is a long range one, in an attempt to set up criteria by which standard courses of treatment employed in early syphilis, might be assessed. It was also hoped that, thereby, arguments might be derived for the improvement of existing methods of therapy. It was felt that a considerable time was necessary for much criteria to be evolved. Accordingly, a standard method of treatment has been adopted, and the results obtained over a period of twelve years have been examined. This standard treatment was difficult to maintain in face of criticism, both from within, and from without, the department. It is hoped that the success of the change of methods of treatment advocated may be its justificaiton. No such homogenous long-range experiment has been met with in the literature. It is widely known that the problems related by the presence of late or chronic syphilis are of a totally different nature from those present in the early stages of disease. Accordingly, an analysis of the results achieved by the varied methods used in the tratment of latent syphilis and late muco-cutaneous syphilis has been incorporated. These sections, by themselves, may afford aid in the guidance of the tratment of such conditions. They will also serve to show up, in contrast, the very different questions raised by early syphilis, and it is hoped they will add force to the conclusions reached regarding the treatment of the early stages. In the course of years much experimental work has been done within these imposed limits. Such work has dealt with the problems raised by late syphilis, by intolerance, with the examination of new drugs designed to treat syphilis, and with many clinical side tracks which proved attractive. Thy are dealt with in the investigation of new drugs designed for the treatment of syphilis is incorporated. No such detailed instruction is found in the literature. The second experiment is concerned with the use of iodine in the treatment of syphilis. The lack of modern detailed clinical experiments led to the commencement of observations in 1923, and these have been continued for over nine years. The number of cases dealt with exceeds 1,750; the number of experiments exceeds 3,500. Complete protocols would make this thesis, already very lengthy, of an intolerable size. The methos of summary has therefore had to be employed, and the mass of observations is compressed into the limits of a single section.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Medicine
• Date of Award: 1935
• Depositing User: Enlighten Team
• Unique ID: glathesis:1935-79984
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 31 Mar 2020 09:09
• Last Modified: 31 Mar 2020 09:09
• URI: https://theses.gla.ac.uk/id/eprint/79984