An Investigation of Some Quinoline and Acridine Derivatives of Possible Therapeutic Value

Glen, William Lawrence (1937) An Investigation of Some Quinoline and Acridine Derivatives of Possible Therapeutic Value. PhD thesis, University of Glasgow.

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In this thesis, some new acridine and quinoline ethene derivatives are described, and these compounds will now be considered in detail. Each series has been confined to a separate section for the sake of clarity, and each of these sections is, as far as possible, complete in itself. In Section I, a series of anil coxapounds of 2:8-diamino acridine is discussed, while sections It, III, and IV are concerned chiefly with a series of ethene derivatives prepared from 5-aldehyde acridine. Thus Section II contains pyridine-acridine ethenes of type (a), while Section III deals with analogous quinoline-acridine ethenes of type (b). (a) In Section IV an unsuccessful attempt was made to prepare acridine-acridine ethenes of the following type. The means whereby substituent groups can be introduced into the acridine ring of the ethene compounds prepared are also briefly discussed in this section. In addition to the compounds mentioned above, a few quinoline ethene and anil derivatives of the type studied by Browning and his collaborators have been prepared. The theoretical portion of this thesis has been reserved largely for discussions of a general nature, results of biological tests, and consideration of negative results or cases of especial difficulty arising out of the preparation of the various compounds studied. It contains therefore, little information on the methods of preparation employed, since this is available in extensons in the experimental section, together with any relevant theoretical considerations;

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Organic chemistry
Date of Award: 1937
Depositing User: Enlighten Team
Unique ID: glathesis:1937-80209
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 02 Mar 2020 21:06
Last Modified: 02 Mar 2020 21:06

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