Unravelling the role of the left and right ventricles in pulmonary arterial hypertension: patient and small animal cardiac MRI studies

Jayasekera, Geeshath (2020) Unravelling the role of the left and right ventricles in pulmonary arterial hypertension: patient and small animal cardiac MRI studies. PhD thesis, University of Glasgow.

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The definite hemodynamic diagnosis of pulmonary hypertension (PH) requires direct measurement of the pulmonary artery pressure by right heart catheterisation. As right heart catheterisation is an invasive test with a small risk of associated morbidity and mortality, diagnostic algorithms have been devised that combines clinical history and examination, cardio- respiratory assessment by non-imaging techniques and subsequently imaging techniques in patients suspected of having PH. The aim of these initial investigations is to establish a tentative diagnosis of PH, help identify the underlying aetiology and to provide information regarding disease severity and determine response to treatment.
Although PH is a disease of the pulmonary vasculature, it is the subsequent right ventricular (RV) failure that is the main cause of morbidity and mortality in PH patient. Thus, RV is the most widely studied of the chambers in PH, however focus has started to move to the left ventricle (LV). Although a disease of the pulmonary circulation and the RV, there is now evidence demonstrating LV abnormalities in PH. Further to this, the atrial chambers offer valuable information when measuring cardiac function as well as in identifying the aetiology of PH. Small animal (rodent) models are increasingly used to identify pathophysiology as well as therapies for PH with the intention of translating the findings to humans. Accurate monitoring of disease in rodents with emphasis on ventricular function and the ability to monitor the disease state without killing the animal is needed.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: pulmonary hypertension, imaging, cardiac MRI, strain, T1 mapping, sugen-hypoxia, right ventricle, left ventricle.
Subjects: R Medicine > R Medicine (General)
Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health > Cardiovascular & Metabolic Health
Supervisor's Name: Radjenovic, Dr. Aleksandra and Peacock, Prof. Andrew
Date of Award: 2020
Depositing User: Dr. Geeshath Jayasekera
Unique ID: glathesis:2020-81612
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 31 Aug 2020 09:16
Last Modified: 31 Aug 2020 09:54
URI: https://theses.gla.ac.uk/id/eprint/81612
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