Synthesis and functionalisation of zirconium Metal-Organic Frameworks for biomedical applications

Boyadjieva, Sophia (2021) Synthesis and functionalisation of zirconium Metal-Organic Frameworks for biomedical applications. PhD thesis, University of Glasgow.

Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.


In recent years, the interest in Metal-Organic Frameworks (MOFs) has grown exponentially due to their properties, such as porosity, robustness, and ease of functionalisation. MOFs are hybrid structures, highly porous and crystalline, consisting of metal clusters, joined together by multidentate organic ligands via coordination bonding. The repeated nature of the bonding between the inorganic ligands leads to the formation of permanently porous structures.

The possibility to tailor the framework to have specific and desired structures and properties gives the opportunity to control the characteristics and behaviour of the MOF for a variety of applications such as gas capture and separation, thin film devices, catalysis, and biomedical uses, such as imaging and drug delivery.

This thesis focuses on the post-synthetic modification of UiO-based frameworks for biomedical applications. This includes attaching naphthalimides as surface reagents for their fluorescent and biocompatible character, to the Zr-based UiO-66, exploring the host-guest relationship between a series of isoreticular Zr-based UiO series and different sized anti-cancer drugs, and the study of Zr- and Hf-based hexagonal-closed pack (hcp) phase of UiO MOFs with two different linkers.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Due to copyright restrictions the electronic version will not be available for viewing after the embargo period has expired.
Keywords: Metal-Organic Framework, MOF, zirconium, drug delivery systems, biomedicine, inorganic chemistry.
Subjects: Q Science > QD Chemistry
Colleges/Schools: College of Science and Engineering > School of Chemistry
Funder's Name: European Research Council (ERC)
Supervisor's Name: Forgan, Professor Ross
Date of Award: 2021
Embargo Date: 3 June 2024
Depositing User: Miss Sophia Boyadjieva
Unique ID: glathesis:2021-82246
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 03 Jun 2021 18:22
Last Modified: 04 Jun 2021 07:54
Thesis DOI: 10.5525/gla.thesis.82246

Actions (login required)

View Item View Item