The synthesis and development of radionuclide based tracers for the imaging of diseases

Burianova, Valeriia (2025) The synthesis and development of radionuclide based tracers for the imaging of diseases. PhD thesis, University of Glasgow.

Abstract

This PhD focused on the development of synthetic methods for the preparation of known and novel PET imaging agents targeting the central nervous system. The first project created a second-generation enantioselective synthesis of [18F]SynVesT-1, a PET imaging agent for the synaptic vesicle protein 2A (SV2A), along with its non-radiofluorinated standard. Additionally, a modification of this route allowed the synthesis of the novel radioligand, [3H]SynVesT-1, for SV2A autoradiography.

The next project focused on the synthesis of novel PET imaging agents for the monocarboxylate transporters-1 and -2. A small library of fluorinated and methoxylated 6 substituted thieno[2,3-d]pyrimidinedione-5-carboxamide analogues was synthesised via an eight-step route. The physicochemical properties of the developed compounds were evaluated using HPLC methodology, with all showing favourable characteristics.

The final project was dedicated to the development of novel fluorescent α-amino acids via derivatisation of tryptophan at C2-position through alkenylation (Horner-Wadsworth-Emmons and Witting) and arylation (Suzuki-Miyaura) reactions. The resulting amino acids showed excellent photophysical properties, solvatochromism and pH sensitivity.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Subjects: Q Science > QD Chemistry
• Colleges/Schools: College of Science and Engineering > School of Chemistry
• Funder's Name: Engineering and Physical Sciences Research Council (EPSRC)
• Supervisor's Name: Sutherland, Professor Andrew
• Date of Award: 2025
• Depositing User: Theses Team
• Unique ID: glathesis:2025-85384
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 13 Aug 2025 07:50
• Last Modified: 13 Aug 2025 07:51
• Thesis DOI: 10.5525/gla.thesis.85384
• URI: https://theses.gla.ac.uk/id/eprint/85384

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