Magnetic resonance imaging assessment of skeletal muscle changes following chronic denervation in the dog

Krivonogova, Olga Vasilievna (2014) Magnetic resonance imaging assessment of skeletal muscle changes following chronic denervation in the dog. MVM(R) thesis, University of Glasgow.

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This study sought to evaluate the effect of presumed chronic denervation (due to brachial plexus mass lesions) on the magnetic resonance imaging (MRI) appearance of muscle in the dog. One of the features of denervation that has been described is fat infiltration; prior to defining the effect of the brachial plexus mass lesions, this study first attempted to define the normal patterns of fat deposition with increasing body condition scores. MRI assessment of subcutaneous and intramuscular fat deposition was compared against two previously described methods of body condition scoring in the dog. There was a significant relationship between the 9-point body score (BCS) assessment and body fat percentages calculated on the basis of girth and hock measurements. Both of these methods correlated well with MRI determination of subcutaneous fat (SCF) thickness in the dorsal lumbar area and with total (dorsal and ventral) SCF in the cervical area. What was evident from the MRI evaluation of fat deposition was that the pattern of fat deposition in these regions differed, being predominantly subcutaneous in the lumbar region, but with fat deposition in both the subcutaneous and intermuscular regions in the cervical region. In both regions the amount of fat deposition increased from cranial to caudal. Intramuscular fat deposition assessed in terms of T1W signal hyperintensity in the lumbar epaxial muscles correlated well with BCS, though for cervical muscles the correlation was weaker and increasing BCS appeared to have less effect on MRI signal change in normal neck muscle. Having decided to focus on brachial plexus mass lesions, the ability to identify the individual proximal thoracic limb muscles by MRI was assessed. Proximal thoracic limb muscles identification and MRI appearance were found to depend on the MRI plane position, relative to the spine of the scapula. Better results for the identification of individual muscles were achieved on images with the plane aligned parallel to the spine of the scapula or at 90 degree angle to it, and with the limbs positioned in extension along the body and symmetrically to each other. Transverse images permitted better muscle detection. MRI of the proximal thoracic limb of 19 dogs with brachial plexus mass lesions showed a mixed pattern of T1W and T2W hyperintensity and variable degrees of muscles atrophy. Mass lesions were found in three shapes – globoid, tubular and fusiform. Multiple lesions were detected in 9 cases, and in 6 out of 9 cases these included lesions within the thoracic cavity. In 9 cases vertebral canal involvement was evident. Mass lesions were best detectable on the short tau inversion recovery sequence (STIR) followed by T2W and T1FatSat with contrast.

Item Type: Thesis (MVM(R))
Qualification Level: Masters
Subjects: S Agriculture > SF Animal culture > SF600 Veterinary Medicine
Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Supervisor's Name: Penderis, Prof. Jacques and Sullivan, Prof. Martin
Date of Award: 2014
Depositing User: Mrs Marie Cairney
Unique ID: glathesis:2014-8627
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 12 Dec 2017 13:22
Last Modified: 23 Jan 2018 08:04

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