Cerebral damage following ischaemic stroke: the role of Angiotensin-(1-7)

Arroja, Mariana Moreira (2018) Cerebral damage following ischaemic stroke: the role of Angiotensin-(1-7). PhD thesis, University of Glasgow.

Abstract

The renin angiotensin system (RAS), a homeostatic system involved in blood pressure and volume control, is implicated in the pathology of several risk factors for ischaemic stroke. Mounting evidence now suggests that the RAS may play a role in the pathophysiology of ischaemic stroke. This is thought to be due to an imbalance between the classical RAS axis, Angiotensin converting enzyme/Angiotensin II/Angiotensin II receptor type I (ACE/Ang II/AT1R), and the counter-regulatory RAS axis, Angiotensin converting enzyme 2/Angiotensin-(1-7)/Mas receptor [ACE2/Ang-(1-7)/MasR]. The counter- regulatory axis has been shown to provide neuroprotection in ischaemic stroke animal models. Therefore, the studies conducted in this thesis aimed to test the neuroprotective potential of Ang-(1-7) as a post-stroke therapy following transient focal cerebral ischaemia. Furthermore, experiments were conducted to test a potential synergistic effect between MasR and alternative Ang II receptor, Angiotensin II receptor type II (AT2R), agonism following stroke.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Ischaemic stroke, renin angiotensin system, angiotensin-(1-7), focal cerebral ischaemia, animal models, MRI.
• Subjects: R Medicine > R Medicine (General)
• Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences; College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
• Funder's Name: Medical Research Council (MRC)
• Supervisor's Name: McCabe, Dr. Christopher and Nicklin, Prof. Stuart and Work, Dr. Lorraine
• Date of Award: 2018
• Depositing User: Dr Mariana Arroja
• Unique ID: glathesis:2018-9010
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 03 May 2018 10:07
• Last Modified: 25 Apr 2019 10:49
• URI: http://theses.gla.ac.uk/id/eprint/9010

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