Investigation of neuropsychiatric aspects of Sydenham’s Chorea: case series review

Punukollu, Mallika (2017) Investigation of neuropsychiatric aspects of Sydenham’s Chorea: case series review. MSc(R) thesis, University of Glasgow.

Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.
Printed Thesis Information:


Hypthesis: There is an association with the severity of chorea symptoms in Sydenham's chorea and psychiatric diagnosis.
Primary Objective: To identify, using a validated, structured diagnostic interview, the prevalence of psychiatric diagnoses before, during, and after the presence of chorea in a regional, clinic-based case series of children and adolescents with a history of Sydenham's chorea.
Method: The study interviewed twelve children who had been diagnosed with SC by Neurology and were referred to a psychiatric liaison team with psychiatric symptoms within the study period. The interview consisted of semi structured validated questionnaire screening tools including the ESSENCE questionnaire, the KIDDIE-SADS PL, and the Chorea rating scale (USCRS) that included a video recording.
Results: Although all twelve children had a history of psychiatric symptoms, all but three children had a history of psychiatric symptoms prior to diagnosis of SC. During and after the chorea developed all children developed new or more severe psychiatric symptoms and there was an overall increase in range of psychiatric symptoms experienced. At the time of the study all but two children were screened as having current psychiatric diagnoses with KSADS-PL. The psychiatric diagnoses were not correlated with whether the child had chorea at the time of the study or not.
Conclusions: The study suggests that the majority of children who develop psychiatric problems in the context of a diagnosis of Sydenham’s chorea are likely to have pre-morbid vulnerability to psychiatric symptoms. New onset of psychiatric symptoms developed in three children following the diagnosis of SC. The remaining nine children already had pre-existing psychiatric symptoms and vulnerabilities however, overall, this latter group of children also reported more symptoms developing after they developed SC.

Item Type: Thesis (MSc(R))
Qualification Level: Masters
Additional Information: Due to confidentiality issues the electronic version is unavailable for viewing, access to the print version is available when any embargo period has expired.
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Supervisor's Name: Minnis, Professor Helen
Date of Award: 2017
Embargo Date: 3 May 2022
Depositing User: Dr Mallika Punukollu
Unique ID: glathesis:2017-9071
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 09 May 2018 11:32
Last Modified: 04 May 2021 07:54

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