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Targeted delivery of biological agents

Greig, Jenny A. (2009) Targeted delivery of biological agents. PhD thesis, University of Glasgow.

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Abstract

Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector. This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Adenovirus, Anti-oxidant, Targeting
Subjects: Q Science > QH Natural history > QH301 Biology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Baker, Professor Andrew H. and Work, Dr. Lorraine M.
Date of Award: 2009
Depositing User: Miss Jenny A. Greig
Unique ID: glathesis:2009-1386
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 15 Jan 2010
Last Modified: 10 Dec 2012 13:38
URI: http://theses.gla.ac.uk/id/eprint/1386

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