Greig, Jenny A. (2009) Targeted delivery of biological agents. PhD thesis, University of Glasgow.
Full text available as:
PDF
Download (7MB) |
Abstract
Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector. This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.
Item Type: | Thesis (PhD) |
---|---|
Qualification Level: | Doctoral |
Keywords: | Adenovirus, Anti-oxidant, Targeting |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Colleges/Schools: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Supervisor's Name: | Baker, Professor Andrew H. and Work, Dr. Lorraine M. |
Date of Award: | 2009 |
Depositing User: | Miss Jenny A. Greig |
Unique ID: | glathesis:2009-1386 |
Copyright: | Copyright of this thesis is held by the author. |
Date Deposited: | 15 Jan 2010 |
Last Modified: | 10 Dec 2012 13:38 |
URI: | https://theses.gla.ac.uk/id/eprint/1386 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year