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Investigation of factors controlling cutaneous circulation in flaps

Tollan, Clare Josephine (2012) Investigation of factors controlling cutaneous circulation in flaps. MD thesis, University of Glasgow.

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Abstract

The aim of this research was to investigate the blood supply to the lower abdomen. This is a commonly used donor site for autologous reconstruction following breast cancer and the flap of tissue used is based on the deep inferior epigastric circulation (DIEP flap) or the superficial inferior epigastric circulation (SIEA flap). A pilot study investigated the feasibility of assessing the vascular territory of multiple blood vessels in the lower abdomen, and also observed the timing of changes in skin blood supply after free flap transfer. Further studies included sampling using microdialysis catheters, from different areas of the flap, around the theoretical time of opening of choke vessels between angiosomes. Manipulation of skin blood flow was initially investigated using capillary malformations as a model, observing current clinical use of EMLA and AMETOP topical anaesthetic pre-laser treatment.

Item Type: Thesis (MD)
Qualification Level: Doctoral
Keywords: DIEP, DIEAP, SIEA, free flap, breast reconstruction, microsurgery, microcirculation, angiosomes, Laser Doppler, confocal microscope, microdialysis
Subjects: R Medicine > RD Surgery
Q Science > QP Physiology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Supervisor's Name: Mac Farlane, Dr. Niall and Mackay, Mr. Iain and Soutar, Mr. David
Date of Award: 2012
Depositing User: Dr CJ Tollan
Unique ID: glathesis:2012-3164
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 10 Feb 2012
Last Modified: 10 Dec 2012 14:04
URI: http://theses.gla.ac.uk/id/eprint/3164

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