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Regulation of the aldosterone synthase gene-role in human hypertension and adrenal corticosteroid production

McManus, Frances (2012) Regulation of the aldosterone synthase gene-role in human hypertension and adrenal corticosteroid production. PhD thesis, University of Glasgow.

Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.

Abstract

Despite many advances in technology and significant levels of funding, the genetic factors that regulate blood pressure in the population remain unclear. The public health implications of this lack of knowledge are conspicuous and a better understanding of the mechanisms behind hypertension would lead to better management of this important risk factor. The myriad of physiological systems involved in maintaining blood pressure can be variably dysregulated in patients with hypertension. Therefore, taking more account of hypertension as a heterogeneous condition may be a useful approach. Given the lack of success in dissecting the genetic factors to date, it seems reasonable to refocus attention on more carefully phenotyped groups of subjects, with the aim of identifying mechanisms specific to them.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Subjects: R Medicine > R Medicine (General)
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Davies, Prof. E. and Connell, Prof. J.
Date of Award: 2012
Embargo Date: 17 August 2015
Depositing User: Mrs Marie Cairney
Unique ID: glathesis:2012-3565
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 17 Aug 2012
Last Modified: 10 Dec 2012 14:08
URI: http://theses.gla.ac.uk/id/eprint/3565

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